Innovation, globalization, and digitalization are transforming every industry. This course focuses on creating new businesses, new markets, and effectiveness through innovation, entrepreneurship, and digital capabilities. Disruptors like Uber, Airbnb and blockchain, outsiders with new, less expensive solutions for customers, threaten entire industries. Apple, Amazon, ChatGPT, and digital currencies have created uncontested markets, delivered higher value, redefined channels, and secured competitive advantages. Blockchain can transform virtually every industry. Entrepreneurs and existing firms are creating innovative environments, products, processes, services, and new business models. Incremental improvements are not enough. We examine successful strategies, business models, frameworks, funding options, barriers, and risks for introducing breakthrough products and services. Topics include business model innovation, artificial intelligence, blockchain, design thinking, lean thinking, organizational learning, agility, and fundraising.