Immunology

What is the immune system and how does it work to protect organisms from danger like infections and cancer? In this comprehensive course, we answer these questions by exploring the structure and function of the immune system, focusing on cellular and molecular mechanisms. Students develop a solid understanding of innate versus adaptive immunity; antigens and antibodies; B cells, T cells, and their receptors; major histocompatibility complex (MHC) proteins; cytokines and chemokines; processes of lymphocyte development and antigen presentation; and the genetics of the immune system. Case studies describe clinical aspects of human immune system function in health and disease including infections (bacterial, viral, fungal, and parasitic), cancers, autoimmune diseases, allergic and other hypersensitivity diseases, immunodeficiencies, transplantations, vaccinations, and medications and other therapeutic agents (including biologics and CAR-T cells) that affect and harness the immune system. Along the way, we touch on broader themes such as the relationship between the immune system and the nervous system, the dynamics of complex systems that operate at different planes of resolution (from the molecular and cellular to whole populations of organisms and the interactions of different species in ecosystems including the human microbiome), and some philosophical and interpretive views of immunity such as how it contributes to identity and how it functions in ways analogous to language. Upon completion of the course, students have a sound understanding of the essential elements of the immune system, preparing them to engage further in this rapidly evolving field.